What is Rofecoxib? A Basic Definition

rofecoxib \rofecoxib\ (Chem. & Med.)
   A chemical
         substance (C17H14O4S,
         molecular weight 314.36)
   used in medicine as an
         analgesic to alleviate pain and
   inflammation; it is a
         synthetic compound, and is marketed by
   Merck & Co. under
         the trade name Vioxx, in
         tablets giving
   dosages of
         12.5 or 25 milligrams. It is classed as a
   non-steroidal
         anti-inflammatory drug (NSAID). Chemically, it
   is
         4-[4-(methylsulfony)phenyl]-3-phenyl-2(5H) furanone. Its
  
         chemical structure contains two phenyl rings and a
         furanone
   ring. It is believed to act by inhibition of
         prostaglandin
   biosynthesis, through inhibition of the
         enzyme
   cyclooxygenase-2 (COX-2); unlike aspirin, it
         does not
   inhibit cyclooxygenase-1.
   [PJC]

Rofecoxib (Vioxx) News, Updated Regularly

A big dose of change prescribed for FDA - Philadelphia Inquirer
January 3, 2009, 11:56 pm

President-elect Barack Obama is prowling for a new head for the U.S. Food and Drug Administration, which, in the eyes of some outraged Americans, is like hunting for someone to put tainted toothpaste back in its tube. In the last several years, the ...

Pricing, regulation squeezed drug industry in 2008 - WTOP Radio
December 31, 2008, 6:28 am

TRENTON, N.J. (AP) - Stricter regulation, a dearth of new blockbuster drugs, increased pressure to lower prices and more intense generic competition hammered the pharmaceutical industry in 2008, but its stocks still weathered the market collapse ...

Patient data could show medicines danger - Tasmanian Examiner
January 2, 2009, 6:25 am

THE national health safety agency is pressing the Federal Government to cross-check the huge bank of information held in the Medicare and pharmaceutical records of patients to curb thousands of avoidable illnesses and deaths caused every year by ...

Damage control for Big Pharma - Newark Star-Ledger
January 3, 2009, 9:33 pm

Stricter regulation, a dearth of new blockbuster drugs, increased pressure to lower prices and more intense generic competition hammered the pharmaceutical industry in 2008, but its stocks still weathered the market collapse better than many other ...

Price and regulatory pressures squeezed drug industry in 2008 ... - Newsday
December 31, 2008, 6:35 am

TRENTON, N.J. (AP) ? Stricter regulation, a dearth of new blockbuster drugs, increased pressure to lower prices and more intense generic competition hammered the pharmaceutical industry in 2008, but its stocks still weathered the market collapse ...

Drug companies voluntarily cut swag to doctors - Seattle Times
December 31, 2008, 12:08 am

To Lehman Brothers, Linens 'n Things and the blank VHS tape, add another U.S. institution that expired in 2008: drug-company trinkets. Starting Thursday, the pharmaceutical industry has agreed to a voluntary moratorium on the kind of branded goodies ...

No more free goodies for U.S. doctors - International Herald Tribune
December 31, 2008, 3:43 am

To Lehman Brothers, the retailer Linens 'n Things and the blank VHS tape, add another American institution that expired in 2008: drug company trinkets. Starting Thursday, the pharmaceutical industry has agreed to a voluntary moratorium on the kind of ...

Sorry, doc, no Botox shirt for you - Raleigh News & Observer
December 31, 2008, 2:17 am

To Lehman Brothers, Linens 'n Things and the blank VHS tape, add another American institution that expired in 2008: drug company trinkets. Starting Jan. 1, the pharmaceutical industry has agreed to a voluntary moratorium on the kind of branded ...

December 2008 - Weblogs.baltimoresun.com
December 28, 2008, 3:57 pm

We're getting the sense that the new blog authored by Joe Steffen, better known as the Prince of Darkness who did Bob Ehrlich's dirty work for years, will be the gift that keeps on giving. In his most recent post , Steffen delights with the detail ...

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Fri Oct 24

• Long-Term Data on Rofecoxib Confirm Cardiovascular Risks - Physician's First Watch: use of rofecoxib was associated with "an early increase in risk [for the combined incidence of myocardial infarction, stroke, and death from cardiovascular , hemorrhagic, and unknown causes] that seems to persist for about 1 year after 3 years of treatment.&quo t;

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