Paroxetine (Paxil) News, Updated Regularly

Year in Review: 2008 was loaded with local health stories - Post-Bulletin
December 29, 2008, 3:56 pm

Many health stories had local connections in 2008. From doctor-of-the-year to anniversaries and mysterious illness, the calendar was packed. ? Early January Mayo Clinic oncologist Dr. Judith Salmon Kaur is named 2007 Physician of the Year by the ...

Leave the Sinking Ship - Huffingtonpost.com
December 30, 2008, 3:54 pm

Andrew Weil, MD and Rustum Roy, PhD also contributed to this article. On December 26, 2008, the Wall Street Journal published "The Touch that Doesn't Heal," an article by Steve Salerno. Without discernible professional credentials in health reportage ...

One Million Americans Now Receive Personalized FDA Drug Safety Alerts ... - Businesswire.com
December 30, 2008, 8:09 am

?Despite enormous investment of time and money in healthcare information technology, patients don?t feel confident that the healthcare system is watching out for them,? said Hugo Stephenson, MD, iGuard.org?s founder. ?iGuard.org is a really ...

Hey Life Sciences Fans, Remember The Deals Back in 2008? - Xconomy
January 4, 2009, 9:03 pm

I recently had coffee with a venture capitalist at the Starbucks across the street from Biogen Idec?s (NASDAQ: BIIB ) headquarters in Kendall Square, and he asked me what I thought were the biggest life sciences deals of 2008. The question is ...

Helping Patients and Physicians - Earthtimes
December 30, 2008, 8:09 am

?Despite enormous investment of time and money in healthcare information technology, patients don?t feel confident that the healthcare system is watching out for them,? said Hugo Stephenson, MD, iGuard.org?s founder. ?iGuard.org is a really ...

6m Bugatti found in Newcastle lock-up - GQ Magazine UK
January 5, 2009, 4:20 am

The relatives of an eccentric doctor were pleasantly surprised to be bequeathed a 1937 Bugatti which, unbeknownst to them, had been gathering dust in a Newcastle lock-up alongside an E Type Jaguar and an Aston Martin. The Type 57S Atalante is one of ...

Time To Have a Little Talk About Those "Women's Magazines?" - Huffingtonpost.com
December 30, 2008, 7:48 am

I admire Caroline Kennedy. Her dignity and her character are striking. So when she made the remark to New York Times's David Halbfinger the other day, "Have you guys ever thought of writing for a woman's magazine or something? ...You're supposed to ...

Beyond baby blues - St. Cloud Times
December 29, 2008, 11:55 pm

It?s supposed to be one of the happiest times in a mother?s life, but the birth of a child can bring on postpartum depression, leaving one with feelings of inadequacy, shame and guilt. ?Postpartum depression is a depression that interferes in ...

Secure your Vista PC in 10 simple steps - ITBusiness.ca
January 5, 2009, 1:21 am

In its fresh-from-the-box configuration, Vista still leaves a chance for your personal data to leak out to the Web through Windows Firewall or for some nefarious bot to tweak your browser settings without your knowledge. But by making a few judicious ...

Casting a light on mental illness - Globe and Mail
December 25, 2008, 3:53 pm

Michael Kirby wants a revolution in the way we regard diseases of the mind, and has established a unique charity to bring it about ... Read the full article Harold A. Maio from FYT Myers, United States Outlying writes: I am not a fan of Kirby. I do ...

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Off-site Paroxetine (Paxil) Links, User Submitted

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• eMedicine Live -Prozac and Other New Generation Anti-Depressan ts Not Effective ? Study Report | Latest: A study in Plos Medicine reports that newer generation anti-depressan ts like fluoxetine (Prozac) venlafaxine, nefazodone, paroxetine are not effective for the mild and the moderatively depressed and show beneficial effect only in the most severely depressed.

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• Generic Paxil | Buy Generic Paxil | Buy chepest discount Paroxetine ...: Paxil (Paroxetine) is an antidepressant . Paxil (Paroxetine) relieves a variety of emotional problems. Generic Paxil (Paroxetine) is used for Treating depression, obsessive-comp ulsive disorder (OCD is a disease marked by unwanted but stubbornly persistent thoughts or unreasonable rituals you feel compelled to repeat ), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), social anxiety disorders, and panic disorders with or without the fear of being in open or public places. For more information visit us at : http://www.sho ppillrx.com

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• Taking Prozac while pregnant may increase risk of birth defects: Nov 24, 2008 (Nursing Times, USA) - Pregnant women who take the antidepressant s fluoxetine (Prozac) and paroxetine (Seroxat) have an increased risk of giving birth to babies with heart anomalies, warn international researchers.

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• Serotonin reuptake inhibitors in pregnancy and the risk of major malformations: a systematic review. [Hum Psychopharmaco l. 2007 Apr;22(3):121- 8.]: The reviewed studies suggest that exposure to fluoxetine, sertraline, citalopram and venlafaxine in early pregnancy is not associated with an increased risk of major congenital malformations. For paroxetine, recent data call for caution in prescribing such a drug in early pregnancy. For the other SRIs, the risk remains substantially undetermined, as data are so far scanty. Given this background, large prospective cohort studies are urgently needed to better assess the risk/benefit ratio of SRIs-treatment during pregnancy.
• Paroxetine and fluoxetine in pregnancy: a prospective, multicentre, controlled, observational study. [Br J Clin Pharmacol. 2008 Jul 11.]: This study suggests a possible association between cardiovascular anomalies and first-trimeste r exposure to fluoxetine.

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• Paroxetine and fluoxetine in pregnancy: a prospective, multicentre, controlled, observational study [Br J Clin Pharmacol. 2008 Jul 11]: Based on prospective data from three Teratogen Information Services, we have demonstrated an increased rate of congenital cardiovascular anomalies among the offspring of fluoxetine- and paroxetine-tre ated mothers.

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• Clinically relevant pharmacokineti c drug interactions with second-generat ion antidepressant s: An update. [Clin Ther. 2008 Jul;30(7):1206 -27.]: Second-generat ion antidepressant s differ in their potential for pharmacokineti c drug interactions. Fluoxetine and paroxetine are potent inhibitors of CYP2D6, fluvoxamine markedly inhibits CYP1A2 and CYP2C19, and nefazodone is a substantial inhibitor of CYP3A4. Therefore, clinically relevant interactions may be expected when these antidepressant s are coadministered with substrates of the pertinent isozymes, particularly those with a narrow therapeutic index. Duloxetine and bupropion are moderate inhibitors of CYP2D6, and sertraline may cause significant inhibition of this isoform, but only at high doses. Citalopram, escitalopram, venlafaxine, mirtazapine, and reboxetine are weak or negligible inhibitors of CYP isozymes in vitro and are less likely than other second-generat ion antidepressant s to interact with co-administere d medications.
• Serotonin toxicity caused by an interaction between fentanyl and paroxetine. [Canadian Journal of Anesthesia 55:521-525 (2008)]: The co-administrat ion of SSRIs and fentanyl may precipitate serotonin toxicity. There must be consideration of this unusual interaction when administering fentanyl to patients established on SSRIs. Physicians should be vigilant of the features of serotonin toxicity developing in such patients.

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