Gefitinib (Iressa) News, Updated Regularly

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Off-site Gefitinib (Iressa) Links, User Submitted

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Mon Jun 23

• Gefitinib-Sens itizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways -- Sordella et al. 305 (5687): 1163 -- Science
• Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs -- Ono and Kuwano 12 (24): 7242 -- Clinical Cancer Research
• Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors -- Zucali et al., 10.1093/annonc /mdn240 -- Annals of Oncology

Fri Feb 15

• Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib -- Gilmer et al. 68 (2): 571 -- Cancer Research: describes a kinetic binding analysis where lapatinib takes much longer to inhibit EGFR than gefitinib

Thu Oct 25

• Bonine-Summers CBT6-4.pdf (application/p df Object): evidence that HGF-induced scattering could be dependent on EGFR - could explain how gefitinib could inhibit cell motility in vivo - but also says c-met is inhibited by 3 uM gefitinib!

Thu Aug 30

• Breast Cancer Expressing the Activated HER2/neu Is Sensitive to Gefitinib In vitro and In vivo and Acquires Resistance through a Novel Point Mutation in the HER2/neu -- Piechocki et al. 67 (14): 6825 -- Cancer Research: IRESSA affecting phosphorylatio n of B1, B2 and B3, also microarray analysis of IRESSA

Tue Aug 21

• Human Breast Cancer Cells Selected for Resistance to Trastuzumab In vivo Overexpress Epidermal Growth Factor Receptor and ErbB Ligands and Remain Dependent on the ErbB Receptor Network -- Ritter et al. 13 (16): 4909 -- Clinical Cancer Research: In this report, we describe the generation of trastuzumab-re sistant BT-474 cells in vivo. The resistant cells retained HER2 gene amplification and trastuzumab binding. They exhibited higher levels of phosphorylated EGFR (P-EGFR) and EGFR/HER2 heterodimers

Wed Jul 11

• Therapeutics Daily - Erlotinib helps in lung cancer after gefitinib failure

Wed Jun 13

• Gefitinib as a First-Line Therapy of Advanced or Metastatic Adenocarcinoma of the Lung in Never-Smokers: another article about Iressa/gefitin ib and advanced adenocarcinoma
• Gefitinib/Ires sa and Brain Metastasis: a long list of articles on the topic of Iressa and brain metastasis
• Influence of Whole-Brain Radiotherapy on Remission of Brain Metastases: another article on iressa from august 2006. it looks like this treatment is still experimental, and this article recommends it for those who are not eligible for local radiosurgery
• Brain Metastasis Responding to Gefitinib Alone: another article on iressa
• Effect of Gefitinib on Brain Metastases From Non-Small Cell Lung Cancer: more on gefitinib (iressa) and non small cell lung cancer brain metastasis. this is a tiny study.

Sun Oct 8

• Costs & the New Treatment Options in Cancer Therapy

Off-site Gefitinib Research Links

If you still need additional information on Gefitinib then we suggest the following off-site resources. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.